New Mononuclear and Binuclear Cu(II), Co(II), Ni(II), and Zn(II) Thiosemicarbazone Complexes with Potential Biological Activity: Antimicrobial and Molecular Docking Study
Autor: | Ahmed Gaber, Walaa F. Alsanie, Rozan Zakaria, A.A.M. Belal, Majid Alhomrani, Abdulhakeem S. Alamri, Essa M. Saied, Ibrahim M. El-Deen, Nader Hassan, Moamen S. Refat |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Thiosemicarbazones
inorganic chemicals Pharmaceutical Science Molar conductivity metal complexes Medicinal chemistry Article transition metals Analytical Chemistry Metal lcsh:QD241-441 chemistry.chemical_compound Transition metal Anti-Infective Agents lcsh:Organic chemistry Drug Discovery Octahedral molecular geometry Proteus vulgaris Physical and Theoretical Chemistry Semicarbazone Chemistry Ligand Organic Chemistry Tetrahedral molecular geometry Cobalt molecular docking Molecular Docking Simulation Zinc 540 Chemie und zugeordnete Wissenschaften methoxy thiosemicarbazone Chemistry (miscellaneous) metallodrugs visual_art Thermogravimetry ddc:540 visual_art.visual_art_medium Molecular Medicine antimicrobial Antibacterial activity Copper Bacillus subtilis |
Zdroj: | Molecules, Vol 26, Iss 2288, p 2288 (2021) Molecules Volume 26 Issue 8 |
ISSN: | 1420-3049 |
Popis: | Herein, we report the synthesis of eight new mononuclear and binuclear Co2+, Ni2+, Cu2+, and Zn2+ methoxy thiosemicarbazone (MTSC) complexes aiming at obtaining thiosemicarbazone complex with potent biological activity. The structure of the MTSC ligand and its metal complexes was fully characterized by elemental analysis, spectroscopic techniques (NMR, FTIR, UV-Vis), molar conductivity, thermogravimetric analysis (TG), and thermal differential analysis (DrTGA). The spectral and analytical data revealed that the obtained thiosemicarbazone-metal complexes have octahedral geometry around the metal center, except for the Zn2+-thiosemicarbazone complexes, which showed a tetrahedral geometry. The antibacterial and antifungal activities of the MTSC ligand and its (Co2+, Ni2+, Cu2+, and Zn2+) metal complexes were also investigated. Interestingly, the antibacterial activity of MTSC- metal complexes against examined bacteria was higher than that of the MTSC alone, which indicates that metal complexation improved the antibacterial activity of the parent ligand. Among different metal complexes, the MTSC- mono- and binuclear Cu2+ complexes showed significant antibacterial activity against Bacillus subtilis and Proteus vulgaris, better than that of the standard gentamycin drug. The in silico molecular docking study has revealed that the MTSC ligand could be a potential inhibitor for the oxidoreductase protein. |
Databáze: | OpenAIRE |
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