Influence of polymorphisms of the beta-2 adrenergic receptor on the presence of exercise-induced bronchospasm in adolescents
| Autor: | Cláudia Regina Cavaglieri, Neiva Leite, Gerusa Einsfeld Milano, Larissa Rosa da Silva, Cássio Leandro Mühe Consentino, Lupe Furtado-Alle, Luciane Viater Tureck, Leilane Lazarotto, Wendell Arthur Lopes |
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| Rok vydání: | 2016 |
| Předmět: |
Economics and Econometrics
medicine.medical_specialty Adolescent Genotype 030204 cardiovascular system & hematology Exercise-Induced Bronchospasm Gastroenterology Bronchial Provocation Tests ADRB2 gene Bronchospasm Broncoespasmo induzido pelo exercício 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine Forced Expiratory Volume Internal medicine Statistical significance Heart rate Materials Chemistry Media Technology medicine Humans Allele Adolescente Gene ADRB2 Polymorphism Genetic business.industry lcsh:RJ1-570 Exercise-induced bronchospasm lcsh:Pediatrics Forestry Original Articles Surgery Asthma Exercise-Induced 030228 respiratory system Beta-2 adrenergic receptor Receptors Adrenergic beta-2 medicine.symptom business human activities |
| Zdroj: | Revista Paulista de Pediatria Revista Paulista de Pediatria v.34 n.1 2016 Revista Paulista de Pediatria (Ed. Português. Online) Sociedade de Pediatria de São Paulo (SPSP) instacron:SPSP Revista Paulista de Pediatria, Vol 34, Iss 1, Pp 24-29 (2016) Revista Paulista de Pediatria, Volume: 34, Issue: 1, Pages: 24-29, Published: MAR 2016 |
| ISSN: | 2359-3482 |
| DOI: | 10.1016/j.rppede.2015.06.021 |
| Popis: | Objective: To determine the influence of polymorphisms of the beta-2 adrenergic receptor (ADRB2) in triggering exercise-induced bronchospasm (EIB) in adolescents. Methods: The subjects were divided into two groups: present EIB (EIB+) (n=45) and absent EIB (EIB−) (n=115). The bronchial provocation test with exercise was performed with a protocol that consisted of walking/running for at least eight minutes at high intensity, i.e., >85% of maximum heart rate, considering EIB+ as a 10% decrease in forced expiratory volume in one second (FEV1). The genotyping of the ADRB2 gene was performed by the Taqman method, using the Step One Plus system. Independent t-test, Mann–Whitney and Chi-square tests, as well as Spearman's correlation coefficient were used for the statistical analysis. Results: Age, body weight, height, FEV1, FVC and FEV1/FVC ratio were lower in the EIB+ group when compared to EIB− (p |
| Databáze: | OpenAIRE |
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