Endogenous inhibitors of human choline acetyltransferase present in alzheimer's brain: preliminary observation
| Autor: | Julian N. Kanfer, Jay W. Pettegrew, Indrapal N. Singh, Chong-Jun Xu |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Aging Magnetic Resonance Spectroscopy Hypothalamus Nerve Tissue Proteins Endogeny Biology Hippocampus Choline O-Acetyltransferase Phosphoserine chemistry.chemical_compound Alzheimer Disease medicine Humans Choline Phospholipids Aged Brain Chemistry chemistry.chemical_classification General Neuroscience Acetyl-CoA Alkaline Phosphatase medicine.disease Choline acetyltransferase Acetylcholine Kinetics Enzyme chemistry Biochemistry Enzyme inhibitor biology.protein Female Neurology (clinical) Geriatrics and Gerontology Alzheimer's disease Developmental Biology Phosphomonoesters |
| Zdroj: | Neurobiology of Aging. 15:643-649 |
| ISSN: | 0197-4580 |
| Popis: | We have previously demonstrated the presence in Alzheimer's disease brain of an endogenous inhibitor of choline acetyltransferase activity. Selected properties of these compounds were investigated. There appear to be two distinct classes of inhibitor present, both phosphomonoesters and nonphosphorylated substances. They are not proteins, pass through 500 mm dialyses membranes and are not lipoidal. There are both different sensitivities of individual control cytosotic activity to inhibition and differences in intrinsic inhibitory activity present in individual Alzheimer's disease brain samples. There is a competitive type of inhibition with respect to acetyl CoA as substrate and a noncompetitive type with respect to choline as substrate. |
| Databáze: | OpenAIRE |
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