Implementation of iMiDEV™, a new fully automated microfluidic platform for radiopharmaceutical production
| Autor: | Christer Halldin, Charlotte Collet, Gilles Karcher, Bengt Långström, Fatiha Maskali, Virginie Hourtane, Sangram Nag, Florian Pineda, Olga Ovdiichuk, Hemantha Mallapura |
|---|---|
| Přispěvatelé: | Nancyclotep- Experimental Imaging Platform = Plate-forme d'imagerie moléculaire, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Université de Lorraine (UL), Karolinska Institutet [Stockholm], PMB/ALCEN, Uppsala Universitet [Uppsala], Service de Médecine Nucléaire [Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Collet, Charlotte |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Quality Control
Fluorine Radioisotopes Computer science Microfluidics Biomedical Engineering Liquid phase Bioengineering Initial activity 02 engineering and technology 01 natural sciences Biochemistry [CHIM] Chemical Sciences [CHIM]Chemical Sciences Process engineering Radiochemistry business.industry 010401 analytical chemistry Radiosynthesis General Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences Fully automated Radiologi och bildbehandling Radiopharmaceuticals 0210 nano-technology business Radiology Nuclear Medicine and Medical Imaging |
| Zdroj: | Lab on a Chip Lab on a Chip, Royal Society of Chemistry, 2021, ⟨10.1039/D1LC00148E⟩ |
| ISSN: | 1473-0197 1473-0189 |
| DOI: | 10.1039/D1LC00148E⟩ |
| Popis: | iMiDEV™ microfluidic system is a new automated tool for a small-scale production of radiopharmaceuticals. This new radiochemistry module utilizes microfluidic cassettes capable of producing diversified radiopharmaceuticals in liquid phase reactions in an automated synthesizer. The user interface is intuitive and designed to give the operator all the information required and to allow driving the synthesis either manually or fully automatically. In this work, we have demonstrated liquid phase reaction and presented the first results of an efficient fully automated [18F]NaF radiosynthesis on the iMiDEV™ platform. Different parameters such as a type of cyclotron targets, initial activity, concentration and volume of the fluoride-18 targetry have been investigated in order to elaborate the optimised radiolabelling of the ligand. Single and double sodium [18F]fluoride synthesis procedures have been successfully developed using two chambers of the cassette. A single-dose of radiotracer was produced in an average radiochemical yield of 87% (decay corrected) within 8 min and quality control tests were performed as per European Pharmacopoeia. Title in Web of Science: Implementation of iMiDEV (TM), a new fully automated microfluidic platform for radiopharmaceutical production |
| Databáze: | OpenAIRE |
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