Ceftiofur attenuates lipopolysaccharide-induced acute lung injury
| Autor: | Xuemei Zhang, Xiaozhe Zhang, Xiao Chu, Dacheng Wang, Xuming Deng, Kan Xu, Yu Song, Songcai Liu, Keji Song |
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| Rok vydání: | 2010 |
| Předmět: |
Lipopolysaccharides
Male Lipopolysaccharide Neutrophils medicine.medical_treatment Acute Lung Injury Immunology Cell Count Pharmacology Lung injury Bronchoalveolar Lavage Mice chemistry.chemical_compound medicine Animals Humans Immunology and Allergy Interleukin 8 Lung Antibacterial agent Mice Inbred BALB C medicine.diagnostic_test business.industry Macrophages Pneumonia respiratory system Cephalosporins respiratory tract diseases Cytokine Bronchoalveolar lavage chemistry Toxicity Cytokines business Ceftiofur |
| Zdroj: | International Immunopharmacology. 10:600-604 |
| ISSN: | 1567-5769 |
| DOI: | 10.1016/j.intimp.2010.02.010 |
| Popis: | Ceftiofur is a new broad-spectrum, third-generation cephalosporin antibiotic for veterinary use. Our laboratory has previously been reported that ceftiofur can modulate early cytokine responses and increase mouse survival in endotoxemia. In the present study, we investigated the effect of ceftiofur on acute lung injury (ALI) induced by lipopolysaccharide (LPS) in vivo. Mice were pretreated with ceftiofur 1h before challenge with a dose of 0.5mg/kg LPS. Mice treated with LPS alone showed marked increased TNF-alpha, IL-6, and IL-8 levels in the bronchoalveolar lavage fluid (BALF). When pretreated with 30mg/kg of ceftiofur, the TNF-alpha, IL-6, and IL-8 levels were significantly decreased. In addition, the W/D ratio of the lung tissue and the number of total cells, neutrophils and macrophages in the BALF significantly decreased at 8h after pretreatment with ceftiofur. Furthermore, ceftiofur markedly attenuated the LPS-induced histological alteration. These studies indicate that ceftiofur significantly decreases the inflammation in a murine model of LPS-mediated ALI and may represent a novel prevention strategy for nonspecific inflammation in the lungs. |
| Databáze: | OpenAIRE |
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