An MHC class II-expressing T cell clone presenting conventional antigen lacks the ability to present bacterial superantigen
| Autor: | David L. Woodland, Christopher Coleclough, Konrad Reske, Uwe Wendling, Deming Sun |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Staphylococcus aureus
T cell T-Lymphocytes Immunology Antigen-Presenting Cells Enterotoxins Interferon-gamma Antigen parasitic diseases MHC class I medicine Immunology and Allergy Cytotoxic T cell Animals Clonal Anergy MHC class II Antigens Bacterial Superantigens biology Antigen processing Chemistry Histocompatibility Antigens Class II Myelin Basic Protein General Medicine MHC restriction Clone Cells Rats medicine.anatomical_structure Rats Inbred Lew biology.protein CD8 |
| Zdroj: | International immunology. 7(7) |
| ISSN: | 0953-8178 |
| Popis: | We have analyzed the response of rat T cells to myelin basic protein (MBP) and the bacterial superantigen, staphylococcal enterotoxin E (SEE). Rat T cells reactive with MBP can respond to SEE presented by spleen cells but not to SEE presented by LOA, a rat T cell clone that expresses both I-A and I-E MHC class II molecules, even though LOA is much more efficient than splenic APC in the presentation of MBP. The inability of LOA to present superantigen is not due to a structural difference in MHC II molecules between LOA and the splenic APC or to differential expression of major accessory/adhesion molecules, including CD2, CD5, CD4 and CD44, on LOA. The non-responsiveness of SEE/LOA-induced T cells differs from anergy, in that such cells do not lose their subsequent responsiveness to either MBP or SEE. Our results demonstrate that: (i) MHC class II molecules (I-A and I-E) alone are insufficient for the activation of T cells by bacterial superantigen, (ii) failure to respond to antigen presented upon inappropriate APC or in inadequate doses may not necessarily represent anergy, and (iii) the quality of the T cell response towards certain ligands can be strongly influenced by the nature of the APC. |
| Databáze: | OpenAIRE |
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