Comparative analysis of the diffusion kurtosis imaging and diffusion tensor imaging in grading gliomas, predicting tumour cell proliferation and IDH-1 gene mutation status
| Autor: | Jing Zhao, Zhu-hao Li, Li Jiang, Man-shi Hu, Yu-liang Wang, Jianping Chu, Da-wei Liu, Xin-bei Li, Yi-su Tian, Jing-yan Wang, Xu Yan, Zhiyun Yang, Yukun Song |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Cancer Research Gene mutation Sensitivity and Specificity Young Adult 03 medical and health sciences 0302 clinical medicine Glioma Fractional anisotropy medicine Humans Prospective Studies Diffusion Kurtosis Imaging Grading (tumors) Aged Cell Proliferation medicine.diagnostic_test Brain Neoplasms business.industry Magnetic resonance imaging Middle Aged medicine.disease Isocitrate Dehydrogenase Diffusion Magnetic Resonance Imaging Diffusion Tensor Imaging Neurology Oncology 030220 oncology & carcinogenesis Mutation Kurtosis Female Neurology (clinical) Neoplasm Grading Nuclear medicine business 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Journal of Neuro-Oncology. 141:195-203 |
| ISSN: | 1573-7373 0167-594X |
| DOI: | 10.1007/s11060-018-03025-7 |
| Popis: | Few studies have applied diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI) for the comprehensive assessment of gliomas [tumour grade, isocitrate dehydrogenase-1 (IDH-1) mutation status and tumour proliferation rate (Ki-67)]. This study describes the efficacy of DKI and DTI to comprehensively evaluate gliomas, compares their results. Fifty-two patients (18 females; median age, 47.5 years) with pathologically proved gliomas were prospectively included. All cases underwent DKI examination. DKI (mean kurtosis: MK, axial kurtosis: Ka, radial kurtosis: Kr) and DTI (mean diffusivity: MD, fractional anisotropy: FA) maps of each metric was derived. Three ROIs were manually drawn. MK, Ka, Kr and FA were significantly higher in HGGs than in LGGs, whereas MD was significantly lower in HGGs than in LGGs (P |
| Databáze: | OpenAIRE |
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