Impaired White Matter Integrity and Social Cognition in High-Function Autism: Diffusion Tensor Imaging Study
| Autor: | Eunjoo Kim, Keun-Ah Cheon, Ji Hye Ha, Woo Young Im, Jaeil Cho, Dong-Ho Song |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
behavioral disciplines and activities
High-function autism White matter 03 medical and health sciences Association fiber Functional connectivity 0302 clinical medicine Fasciculus Fractional anisotropy mental disorders medicine Inferior longitudinal fasciculus Biological Psychiatry biology business.industry Superior longitudinal fasciculus biology.organism_classification medicine.disease Brain network 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Diffusion tensor imaging Autism Original Article business Neuroscience 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Psychiatry Investigation |
| ISSN: | 1976-3026 1738-3684 |
| Popis: | Objective It is known that many of the cognitive and social deficits associated with autism can arise from abnormal functional connectivity between brain networks. This aberrant functional connectivity in autism spectrum disorders (ASD) can be explained by impaired integrity of white matter tracts that link distant regions of the networks. Methods We investigated white matter in 9 children with high-function autism (HFA) compared to 13 typically developing controls using diffusion tensor imaging (DTI). The aim of this research is to provide supporting evidence for abnormalities in neural connectivity as an underlying pathophysiology of the main characteristics of ASD. Results We found impairment of neural connectivity, mainly in association fiber tracts as evidenced by decreased fractional anisotropy (FA), the index of white matter integrity, of these tracts. Among them, inferior fronto-occipital fasciculus (IFOF) had a significant relationship with ADI-R score. The inferior longitudinal fasciculus (ILF) and superior longitudinal fasciculus (SLF) also showed decreased FA. Decreased FA of ILF and SLF had negative correlations with scores of social interaction. Conclusion These findings suggest that widespread abnormalities in association fiber tracts may contribute to both core and associated symptoms of ASD. |
| Databáze: | OpenAIRE |
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