Effects of glutamine supplementation on kidney of diabetic rat
| Autor: | Claudia J. Lagranha, Telma Maria Tenório Zorn, Rodolfo Favaro Ribeiro, Tatiana Carolina Alba-Loureiro |
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| Rok vydání: | 2009 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Kidney Cortex Arginine Nitrogen Glutamine Renal cortex Interleukin-1beta Kidney Glomerulus Clinical Biochemistry Blood sugar Kidney Severity of Illness Index Biochemistry Diabetes Mellitus Experimental Glomerulonephritis Glycosuria Internal medicine Diabetes mellitus medicine Animals Diabetic Nephropathies Rats Wistar Interleukin 6 Sclerosis biology Interleukin-6 Contraindications Organic Chemistry Kidney metabolism medicine.disease Rats medicine.anatomical_structure Endocrinology Gene Expression Regulation Dietary Supplements biology.protein |
| Zdroj: | Amino Acids. 38:1021-1030 |
| ISSN: | 1438-2199 0939-4451 |
| DOI: | 10.1007/s00726-009-0310-3 |
| Popis: | Glutamine is the most important donor of NH(3) in kidney playing an important role in acid-base buffering system. Besides this effect, glutamine presents many other relevant functions in the whole body, such as a precursor of arginine in adult and neonates. In addition to these effects, some studies have shown that glutamine can potentiate renal disease. In the present study, the effect of short-term treatment (15 days) with glutamine on control and diabetic rats was investigated. Using biochemical, histological and molecular biology analysis from control and diabetic rats we verified that glutamine supplementation increase in pro-inflammatory interleukins (IL)-1beta and IL-6 content in renal cortex and induce alteration in glomerular characteristics. This study showed that short-term treatment with glutamine in association with increased glucose levels could cause important alterations in glomerular morphology that may result in fast progression of kidney failure. |
| Databáze: | OpenAIRE |
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