Neuroendocrine Correlates of the Type a Behavior Pattern: A Review and New Hypotheses
| Autor: | Andrew B. Littman, Peter Halperin, Maurizio Fava |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Neurotransmitter Agents
medicine.medical_specialty Sympathetic nervous system Heart disease Dehydroepiandrosterone Sulfate medicine.drug_class Stressor Coronary Disease Type A Personality Type A and Type B personality theory Dehydroepiandrosterone medicine.disease Androgen Hormones Coronary artery disease Psychiatry and Mental health Endocrinology medicine.anatomical_structure Internal medicine medicine Humans Clinical significance Arousal Psychology Neuroscience |
| Zdroj: | The International Journal of Psychiatry in Medicine. 17:289-307 |
| ISSN: | 1541-3527 0091-2174 |
| DOI: | 10.2190/27le-67ju-0453-jd27 |
| Popis: | Various studies have tried to identify the possible neuroendocrine correlates of the action/emotion complex defined as Type A behavior pattern. Type A subjects have been observed quite consistently to respond to laboratory stressors with a greater sympathetic nervous system response than Type B subjects. There also seems to be a trend towards a hyperactivity of the hypothalamic-pituitary-adrenocortical axis in Type A individuals. The clinical relevance of these findings lies in the fact that there is an increasing clinical and laboratory evidence of a pathogenic role of catecholamines in coronary artery disease (CAD) and that some of these neuroendocrine correlates might actually be the mediators of the risk of CAD conferred by the Type A behavior pattern. We hypothesize that dehydroepiandrosterone-sulfate (DHEA-S), an adrenal weak androgen, is inversely correlated with the degree of Type A behavior pattern and this hypothesis seems to be confirmed by the results of a preliminary investigation that we have conducted. |
| Databáze: | OpenAIRE |
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