Serum level of S100B in vitiligo patients: Is it a marker of disease activity?
| Autor: | Doaa A E Abou-Taleb, Dalia Tarik Kamal, Aya Y. Badran, Ahmed S. Gomaa, Randa A. El Zohne, Reham I El-Mahdy |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Vitiligo S100 Calcium Binding Protein beta Subunit Dermatology Disease Sensitivity and Specificity Severity of Illness Index Gastroenterology Disease activity Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Quantitative assessment Humans Prospective Studies Child skin and connective tissue diseases integumentary system Receiver operating characteristic business.industry Melanoma Area under the curve Curve analysis Middle Aged medicine.disease Case-Control Studies 030220 oncology & carcinogenesis Female business Biomarkers |
| Zdroj: | Australasian Journal of Dermatology. 62 |
| ISSN: | 1440-0960 0004-8380 |
| DOI: | 10.1111/ajd.13462 |
| Popis: | Background Vitiligo is a chronic depigmentary skin disorder, characterised clinically by the development of white macules and or patches caused by loss of epidermal melanocytes. S100B is a dual function protein released from epidermal melanocytes in response to injury. It considered a possible marker of disease activity in both malignant melanoma and vitiligo. Aim of the study To estimate the serum level of S100B level in vitiligo patients and correlate its level with disease activity and various disease parameters. Patients and methods Sixty vitiligo patients and 60 healthy volunteers as controls were included in the study. Vitiligo Area Severity Index (VASI) and Vitiligo Disease Activity (VIDA) scores were estimated for each patient. Quantitative assessment of S100B level using ELISA technique was done for all participants. Results S100B level was significantly correlated with the presence of vitiligo (P = 0.01), while it showed no correlation with the disease activity using VASI or VIDA scores. As regards the receiver operating characteristic (ROC) curve analysis of S100B for diagnosis and discrimination of vitiligo, serum S100B showed area under the curve (AUC) of 0.781 with 73.3% sensitivity and 80% specificity. Conclusion The serum level of S100B was related to the presence of vitiligo, but its level did not show any relation to the disease activity using either VASI and VIDA scores or various disease parameters. |
| Databáze: | OpenAIRE |
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