Digest it all

Autor: Mario Mauthe, Harm H. Kampinga, Mark S. Hipp, Fulvio Reggiori
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Mauthe, M, Kampinga, H H, Hipp, M S & Reggiori, F 2023, ' Digest it all : the lysosomal turnover of cytoplasmic aggregates ', Trends in Biochemical Sciences, vol. 48, no. 3, pp. 216-228 . https://doi.org/10.1016/j.tibs.2022.09.012
ISSN: 0968-0004
Popis: Aggrephagy describes the selective lysosomal transport and turnover of cytoplasmic protein aggregates by macro-autophagy. In this process, protein aggregates and conglomerates are polyubiquitinated and then sequestered by autophagosomes. Soluble selective autophagy receptors (SARs) are central to aggrephagy and physically bind to both ubiquitin and the autophagy machinery, thus linking the cargo to the forming autophagosomal membrane. Because the accumulation of protein aggregates is associated with cytotoxicity in several diseases, a better molecular understanding of aggrephagy might provide a conceptual framework to develop therapeutic strategies aimed at delaying the onset of these pathologies by preventing the buildup of potentially toxic aggregates. We review recent advances in our knowledge about the mechanism of aggrephagy.
Databáze: OpenAIRE
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