Zebrafish Genetic Map with 2000 Microsatellite Markers
| Autor: | J. Ziniti, F. de Sauvage, Chäng Sim, Mark C. Fishman, D. Jackson, N. Shimoda, S. Kaplan, Howard J. Jacob, E. Yamada, Ela W. Knapik |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Genetics Genome Positional cloning Genetic Linkage Biology Physical Chromosome Mapping biology.organism_classification Centimorgan Gene mapping Genetic linkage Microsatellite Repeat Mutation Animals Microsatellite Female Cloning Molecular Zebrafish Gene Library Microsatellite Repeats Genetic screen |
| Zdroj: | Genomics. 58:219-232 |
| ISSN: | 0888-7543 |
| DOI: | 10.1006/geno.1999.5824 |
| Popis: | The zebrafish is the first vertebrate organism used for large-scale genetic screens seeking genes critical to development. These screens have been quite successful, with more than 1800 recessive mutations discovered that speak to morphogenesis of the vertebrate embryo. The cloning of the mutant genes depends on a dense genetic map. The 2000 markers we present here, using microsatellite (CA) repeats, provides 1.2-cM average resolution. One centimorgan in zebrafish is about 0. 74 megabase, so, for many mutations, these markers are close enough to begin positional cloning by YAC walks. |
| Databáze: | OpenAIRE |
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