Rakanmakilactones A—F, New Cytotoxic Sulfur-Containing Norditerpene Dilactones from Leaves of Podocarpus macrophyllus var. maki

Autor:	Hyun-Sun Park, Yutaka Aoyagi, Koichi Takeya, Naoki Yoda, Haruhiko Fukaya
Rok vydání:	2004
Předmět:	Terpene Podocarpus macrophyllus biology Chemistry Stereochemistry Organic Chemistry Drug Discovery Cytotoxic T cell General Medicine biology.organism_classification Sulfur containing Biochemistry Two-dimensional nuclear magnetic resonance spectroscopy
Zdroj:	ChemInform. 35
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200420179
Popis:	Six new S-containing norditerpene dilactones, rakanmakilactones A–F ( 5 – 10 ), were isolated from the leaves of Podocarpus macrophyllus D. Don var. maki Endl., along with four known norditerpene dilactones ( 1 – 4 ). Their structures, stereochemistry and absolute configurations were determined by spectroscopic studies (HRMS, IR, 1 H, 13 C and 2D NMR), and single-crystal X-ray analyses. Rakanmakilactones were found to have a cytotoxic effect against P388 murine leukemia cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b106d964e65320dbf46f7a93e533b0fc https://doi.org/10.1002/chin.200420179 Zobrazit plný text záznamu Plný text