Conductively coupled flexible silicon electronic systems for chronic neural electrophysiology
| Autor: | Limei Tian, John A. Rogers, Yishan Zhong, Mackenna Hill, Jize Zhang, Yisong Chen, Guanhua Fang, Ki Jun Yu, Charles Wang, Jahyun Koo, Yiding Zhong, Enming Song, Jinghua Li, Haina Du, Jonathan Viventi, Chia-Han Chiang |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Silicon Materials science Models Neurological chemistry.chemical_element Nanotechnology 02 engineering and technology Multiplexing law.invention 03 medical and health sciences law Electronics Charge injection Electronic systems Electrodes Multidisciplinary 021001 nanoscience & nanotechnology Flexible electronics Active matrix Electrophysiological Phenomena Coupling (physics) 030104 developmental biology chemistry PNAS Plus 0210 nano-technology |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 115(41) |
| ISSN: | 1091-6490 |
| Popis: | Materials and structures that enable long-term, intimate coupling of flexible electronic devices to biological systems are critically important to the development of advanced biomedical implants for biological research and for clinical medicine. By comparison with simple interfaces based on arrays of passive electrodes, the active electronics in such systems provide powerful and sometimes essential levels of functionality; they also demand long-lived, perfect biofluid barriers to prevent corrosive degradation of the active materials and electrical damage to the adjacent tissues. Recent reports describe strategies that enable relevant capabilities in flexible electronic systems, but only for capacitively coupled interfaces. Here, we introduce schemes that exploit patterns of highly doped silicon nanomembranes chemically bonded to thin, thermally grown layers of SiO(2) as leakage-free, chronically stable, conductively coupled interfaces. The results can naturally support high-performance, flexible silicon electronic systems capable of amplified sensing and active matrix multiplexing in biopotential recording and in stimulation via Faradaic charge injection. Systematic in vitro studies highlight key considerations in the materials science and the electrical designs for high-fidelity, chronic operation. The results provide a versatile route to biointegrated forms of flexible electronics that can incorporate the most advanced silicon device technologies with broad applications in electrical interfaces to the brain and to other organ systems. |
| Databáze: | OpenAIRE |
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