Is short‐term antidepressant treatment effective and safe in bipolar depression? Results from an observational multicenter study
| Autor: | Liliana Dell'Osso, Caterina Franceschini, Laura Musetti, Claudia Del Grande, Erika Cambiali, Antonio Tundo, Luca Proietti, Rocco de Filippis |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
antidepressants
bipolar depression efficacy short-term treatment suicidality switch medicine.medical_specialty Bipolar Disorder medicine.drug_class Suicide Attempted 03 medical and health sciences 0302 clinical medicine Rapid cycling Internal medicine mental disorders medicine Humans Pharmacology (medical) Depression (differential diagnoses) Suicide attempt business.industry Mood stabilizer Antidepressive Agents 030227 psychiatry Psychiatry and Mental health Neurology Multicenter study Antidepressant Observational study Neurology (clinical) medicine.symptom business Mania 030217 neurology & neurosurgery Antipsychotic Agents |
| Zdroj: | Human Psychopharmacology: Clinical and Experimental. 36 |
| ISSN: | 1099-1077 0885-6222 |
| DOI: | 10.1002/hup.2773 |
| Popis: | Objectives To investigate the short-term effectiveness and the short-term and long-term safety of acute antidepressant (AD) treatment of bipolar depression in a naturalistic setting. Methods Patients with bipolar (n = 86) or unipolar (n = 111) depression were consecutively recruited and treated with AD (combined with mood stabilizer [MS] and/or second-generation antipsychotics in bipolar depression). Exclusion criteria were mixed depression, high mood instability, previous predominantly mixed depression (both bipolar and unipolar depression), rapid cycling course and previous switch AD-emerging (bipolar depression). Results After 12 weeks of treatment, no difference was found in remission, response and improvement rates between bipolar and unipolar depression. Concerning short-term safety, switching and suicidality did not differ significantly between the two groups, and no suicide attempt was observed. Concerning long-term safety, patients with bipolar depression had a significant reduction of depressive and total recurrences during the year of follow-up, compared to the year before entering the study, without significant changes in (hypo)mania and mixed depression recurrences, and suicide rates. Conclusions Acute AD treatment of bipolar depression is effective in the short-term and safe in the short- and long-term, when administered in combination with MSs and/or second-generation antipsychotics, with a low risk of switch, mixed depression and cycle acceleration. |
| Databáze: | OpenAIRE |
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