Tumor-Associated Macrophages as Potential Targets for Anti-Cancer Activity of Marine Invertebrate-Derived Compounds
| Autor: | Lyudmila S. Dolmatova, Igor Yu. Dolmatov |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Drug business.industry Macrophages media_common.quotation_subject medicine.medical_treatment Cancer therapy Cancer Marine invertebrates medicine.disease Invertebrates Phenotype Metastasis Cancer immunotherapy Neoplasms Tumor-Associated Macrophages Drug Discovery Tumor Microenvironment Cancer research medicine Animals Immunotherapy business Reprogramming media_common |
| Zdroj: | Current Pharmaceutical Design. 27:3139-3160 |
| ISSN: | 1381-6128 |
| DOI: | 10.2174/1381612827666210319125652 |
| Popis: | Tumor-associated macrophages (TAMs) are M2 phenotype dominant and promote tumor growth and metastasis. The new cancer treatment strategy includes TAM targeting and is aimed primarily at reprogramming TAMs toward the M1 phenotype or reducing the number and activity of M2 macrophages. Several marine invertebrate-derived drugs, combining efficacy and a low level of side effects, were approved for use in the cancer therapy. The mechanisms of action of some of them include TAM targeting. The review includes data showing immunomodulatory properties of these already approved anticancer drugs and drug candidates in clinical development which additionally incorporate data from screening studies of new substances from marine invertebrates. Based on screening data, the most promising marine compounds for cancer immunotherapy are supposed. |
| Databáze: | OpenAIRE |
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