Acute lipase-induced panniculitis in rats with ligated veins of the hindlimb: a contribution to the role of acute panniculitis as a precursor of lipodermatosclerosis of venous disease
| Autor: | Jochanan H. Boss, Daniel Yeshurun, Samuel Eldar, Ines Misselevich, Jorge G. Mogilner, Jacob Bejar, Jochanan E. Naschitz, Zvi Steiner |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Pathology medicine.medical_specialty Panniculitis Femoral vein Dermatology Hindlimb Biochemistry Veins Venous stasis Rats Sprague-Dawley Fibrosis Animals Medicine Saphenous Vein Vascular Diseases Lipodermatosclerosis Ligation Molecular Biology Subcutaneous fibrosis Skin business.industry Lipase Anatomy Femoral Vein medicine.disease Rats body regions Disease Models Animal Adipose Tissue Venous Insufficiency Acute Disease Female medicine.symptom business |
| Zdroj: | Journal of Dermatological Science. 19:9-16 |
| ISSN: | 0923-1811 |
| Popis: | The authors studied the effect of ligation of the femoral and saphenous veins on the evolution of lipase injection-induced subcutaneous fibrosis and inflammation in the rats' hindlimbs. The superficial muscular fascia was thickened and the number of veins was increased 3 days and 3 weeks after vein ligation; both abnormalities disappeared 6 weeks postoperatively. Vein ligation did not quantitatively affect fascial thickening or fibrosing panniculitis in hindlimbs injected with lipase 6 weeks prior to sacrifice. The results contradict the proposition that lipase-induced injury of rats' subcutaneous tissues compromised by venous stasis may lead to a persistent chronic inflammation and fibrosis of the subcutaneous-fascial complex duplicating lipodermatosclerosis in man. |
| Databáze: | OpenAIRE |
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