Activity of NA+/H+ exchangers alters aquaporin-mediated water transport in human placenta
| Autor: | Alicia E. Damiano, Valeria Dietrich |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Sodium-Hydrogen Exchangers
CIENCIAS MÉDICAS Y DE LA SALUD Placenta Intracellular pH NHES Ciencias de la Salud Aquaporin Syncytiotrophoblasts Aquaporins AQPS PHI WATER TRANSPORT Syncytiotrophoblast Pregnancy medicine Humans Transcellular Water transport Chemistry Water Obstetrics and Gynecology Biological Transport Trophoblasts Cell biology Otras Ciencias de la Salud Sodium–hydrogen antiporter medicine.anatomical_structure Reproductive Medicine Biochemistry Female Homeostasis Developmental Biology |
| Zdroj: | Placenta. 36:1487-1489 |
| ISSN: | 0143-4004 |
| DOI: | 10.1016/j.placenta.2015.09.014 |
| Popis: | The intracellular pH (pHi) of syncytiotrophoblasts is regulated, in part, by Na+/H+ exchanger (NHE)-1, NHE-2, and NHE-3. Failures in pHi homeostasis could alter critical cellular functions such as water transport and cell volume. Here, we evaluated whether alterations in syncytiotrophoblast pHi could modify water uptake mediated by aquaporins (AQPs) and the contribution of NHEs to this mechanism. We showed that changes in syncytiotrophoblast pHi did not affect water uptake in the presence of functional NHEs. However, inhibition of NHEs alters transcellular water transport mediated by AQPs in acidosis. These results suggest an interaction between placental AQPs and NHEs in the regulation of water uptake during acidotic states. Fil: Dietrich, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina Fil: Damiano, Alicia Ermelinda. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Biología Celular y Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina |
| Databáze: | OpenAIRE |
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