National trends in population rates of opioid‐related mortality, hospitalization and emergency department visits in Canada between 2000 and 2017. A population‐based study
| Autor: | Meixi Chen, Martin Cooke, Susan J. Elliott, Feng Chang, Mhd Wasem Alsabbagh |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Canada
Population 030508 substance abuse Medicine (miscellaneous) 03 medical and health sciences symbols.namesake 0302 clinical medicine Case fatality rate Humans Medicine 030212 general & internal medicine National trends Poisson regression education Retrospective Studies education.field_of_study business.industry Mortality rate Retrospective cohort study Emergency department Analgesics Opioid Hospitalization Population based study Psychiatry and Mental health symbols Emergency Service Hospital 0305 other medical science business Demography |
| Zdroj: | Addiction. 116:3482-3493 |
| ISSN: | 1360-0443 0965-2140 |
| DOI: | 10.1111/add.15571 |
| Popis: | Background and aims Existing assessments of the time-trends of opioid-related mortality, hospitalization and emergency department visits in Canada have relied mainly on provincial databases, while national assessments generally do not provide information before 2016. We aimed to estimate Canadian national time trends in opioid-related mortality from 2000 to 2017 and opioid-related hospitalization and emergency department visits between 2000 and 2012. Design Retrospective cohort study. Setting and participants Residents of all Canadian provinces and territories for which comparable data were available from 2000 to 2017. Measurements We identified opioid-related mortality, hospitalization and emergency department visits using validated algorithms using ICD codes from administrative databases. We calculated crude rates and sex- and age-adjusted rates per million. For hospitalizations, we calculated case-fatality, 90-day and 365-day all-cause mortality and opioid-related re-hospitalization rates. We used Poisson regression to examine the significance of the time trend. Findings From 2000 to 2017, the adjusted opioid mortality rate in Canada (outside Quebec) increased significantly by 592.9% (from 20.0 opioid deaths per million in 2000 to 118.3 in 2017). The highest year-to-year increases were from 2015 to 2016 (31.8%) and from 2016 to 2017 (52.2%). The adjusted hospitalizations doubled significantly during the study period (an increase of 103.7%, from 159.7 opioid hospitalizations per million Canadians in 2000 to 325.3 in 2012). The adjusted rate of emergency department visits increased significantly by 188.7% (from 280.6 per million in 2000 to 810.1 in 2012). Case-fatality was 2.3% overall and was mainly constant during the study period. Both 90- and 365-day all-cause mortality increased significantly between 2000 and 2011 (from 1.7 to 3.1% and 3.9 to 7.4%, respectively), while re-hospitalization for opioid-related diagnoses was reduced (from 7.8 to 6.4% and 14.2 to 12.9%, respectively). Conclusions Opioid-related mortality, hospitalization and emergency department visits in Canada have been increasing gradually since 2000. |
| Databáze: | OpenAIRE |
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