Porcine osteochondrosis: Deficiencies in transforming growth factor-? and insulin-like growth factor-I
| Autor: | Chris Goddard, S. Ekman, B.H. Thorp, S. B. Jakowlew |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Cartilage
Articular Male medicine.medical_specialty Swine Endocrinology Diabetes and Metabolism Cartilage disorder medicine.medical_treatment Biology Antibodies Chondrocyte Endocrinology Transforming Growth Factor beta Internal medicine medicine Animals Orthopedics and Sports Medicine Insulin-Like Growth Factor I Endochondral ossification Osteochondritis Swine Diseases Hyaline cartilage Cartilage Growth factor medicine.disease Immunohistochemistry medicine.anatomical_structure Osteochondrosis Epiphyses Transforming growth factor |
| Zdroj: | Calcified Tissue International. 56:376-381 |
| ISSN: | 1432-0827 0171-967X |
| Popis: | Osteochondrosis and dyschondroplasia are common multifocal disturbances of endochondral ossification in many species of domestic animals, and are characterized by the retention of avascular cartilage. These cartilage disorders are characterized by a failure of chondrocyte differentiation, matrix mineralisation and its replacement by bone. Rabbit polyclonal antibodies to transforming growth factor-beta (TGF-beta) and to insulin-like growth factor-I (IGF-I) were used to detect the two growth factors in normal and osteochondrotic porcine epiphyses. In the normal pig epiphyses IGF-I and TGF-beta were present in the chondrocytes of the epiphyseal hyaline cartilage and IGF-I was readily localised to the hypertrophic chondrocytes in the growth cartilage adjacent to the epiphyseal ossification centre. Both growth factors were found to be deficient in chondrocytes at sites of osteochondrosis. Both these growth factors are thought to be involved in the cascade of events associated with chondrocyte function during endochondral ossification. Deficiencies in TGF-beta and IGF-I demonstrated in porcine osteochondrosis and previously shown in avian dyschondroplasia suggest further similarities in the pathogenesis of these conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink