Lower anxiety and a decrease in agonistic behaviour in Lsamp-deficient mice
| Autor: | V. Matto, Sulev Kõks, Sirli Raud, Paula Reemann, Kaido Kurrikoff, Mari-Anne Philips, Mario Plaas, Kaarel Nurk, Eero Vasar, Tanel Visnapuu, Paavo Mardi, Jürgen Innos, Indrek Heinla, Este Leidmaa |
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| Rok vydání: | 2010 |
| Předmět: |
Cell Adhesion Molecules
Neuronal Gene Expression Anxiety GPI-Linked Proteins Behavioral Neuroscience Exon Mice Agonistic behaviour medicine Animals GABRA2 Fear conditioning Receptor Mice Knockout biology Behavior Animal GABAA receptor Glutamate Decarboxylase Brain Receptors GABA-A Phenotype Mice Inbred C57BL biology.protein medicine.symptom Psychology Neuroscience Agonistic Behavior |
| Zdroj: | Behavioural brain research. 217(1) |
| ISSN: | 1872-7549 |
| Popis: | In rodents, the Lsamp gene has been implicated in trait anxiety, fear reaction and fear conditioning. Human data link the LSAMP gene to several psychiatric disorders. In this study, we presented a general phenotypic characterization of Lsamp gene-deficient mouse line, created by deleting exon 1b. These mice displayed no gross sensory-motor deficiencies, no overt abnormalities and performed normally in memory and learning tests. However, they responded with increased activity to new environments. Moreover, they displayed reduced anxiety and notable deviations in social behaviour, such as lack of whisker trimming, reduced aggressiveness and reduced dominance. One possible explanation for the anxiolytic-like effect of the deletion of the Lsamp gene is a shift in balance in the Gabra1 and Gabra2 genes in the temporal lobe in favor of the Gabra2 transcript, encoding α2 subunit of GABA(A) receptors that mediate the stimulating effect of GABA agonists. The overall phenotype of Lsamp-deficient mice, characterized by decreased anxiety and several alterations in social behaviour, makes them a good model for studying the molecular mechanisms behind inadequate social behaviours observed in several psychiatric disorders. |
| Databáze: | OpenAIRE |
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