HLA-DR expression in tumor epithelium is an independent prognostic indicator in esophageal adenocarcinoma patients
| Autor: | Mary Clare Cathcart, Ronan Feighery, Jenny A. Watson, Margaret R. Dunne, Naoimh J. O’Farrell, Narayanasamy Ravi, John V. Reynolds, Brendan Doyle, Adriana J. Michielsen, Jacintha O'Sullivan, Elizabeth J. Ryan, Katie E. O’Sullivan, Elaine W. Kay |
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| Jazyk: | angličtina |
| Předmět: |
0301 basic medicine
Oncology Male Cancer Research Inflammation-associated cancer Survival Esophageal Neoplasms Kaplan-Meier Estimate Prognostic markers 0302 clinical medicine Barrett’s esophagus Esophagitis Immunology and Allergy Aged 80 and over Tissue microarray Middle Aged Prognosis Immunohistochemistry medicine.anatomical_structure 030220 oncology & carcinogenesis Disease Progression Adenocarcinoma Original Article Female Esophageal adenocarcinoma Adult medicine.medical_specialty Immunology 03 medical and health sciences Barrett Esophagus Esophagus Internal medicine medicine Biomarkers Tumor Humans Aged business.industry HLA-DR Cancer Epithelial Cells HLA-DR Antigens medicine.disease Epithelium 030104 developmental biology Dysplasia Tissue Array Analysis Barrett's esophagus Stromal Cells business Precancerous Conditions |
| Zdroj: | Cancer Immunology, Immunotherapy |
| ISSN: | 0340-7004 |
| DOI: | 10.1007/s00262-017-1983-1 |
| Popis: | Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor prognosis, and incidence is increasing rapidly in the Western world. Measurement of immune markers has been shown to have prognostic significance in a growing number of cancers, but whether this is true for EAC has yet to be evaluated. This study aimed to characterize HLA-DR expression in the esophagus across the inflammation to cancer progression sequence and to assess the prognostic significance of HLA-DR expression in EAC. Tissue microarrays (TMA) were constructed from esophageal tissue taken from patients at different stages in the cancer progression sequence; normal, esophagitis, Barrett’s esophagus (BE), low- and high-grade dysplasia (LGD, HGD) and EAC. HLA-DR expression in tissue epithelium and stroma was assessed by immunohistochemistry. HLA-DR expression increased early in the inflammation to cancer progression sequence; with higher expression detected in esophagitis and BE compared to normal tissue. Patients with low ( |
| Databáze: | OpenAIRE |
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