Saliva/serum ghrelin, obestatin and homocysteine levels in patients with ischaemic heart disease
| Autor: | Sara Sebnem Kilic, Okhan Akin, Nermin Kilic, Yüksel Bek, Hasan Alacam, Fazilet Erman, Haci Kemal Erdemli, Necati Dagli, Suleyman Aydin |
|---|---|
| Přispěvatelé: | OMÜ |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Saliva medicine.medical_specialty Homocysteine 030209 endocrinology & metabolism Homocysteine levels 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine In patient Vitamin B12 saliva business.industry Cardiovascular Topics digestive oral and skin physiology General Medicine homocysteine Obestatin 030104 developmental biology Endocrinology chemistry ghrelin obestatin Ischaemic heart disease Ghrelin ischaemia Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiovascular Journal of Africa |
| Popis: | WOS: 000405948700007 PubMed: 28759087 Background: We aimed to compare ghrelin, obestatin, homocysteine (Hcy), vitamin B-12 and folate levels in the serum and saliva of ischaemic heart disease patients. Methods: Serum and saliva were collected from 33 ischaemic heart disease (IHD) patients and 28 age- and body mass index-matched healthy individuals. Levels of acylated and desacylated ghrelin, obestatin and Hcy were determined using the ELISA method. Results: Acylated ghrelin, desacylated ghrelin and obestatin levels in the saliva were found to be higher than those in the serum of the control group, while acylated and desacylated ghrelin levels in the saliva were significantly lower than those in the serum. Obestatin levels were higher in IHD patients (p = 0.001). Saliva and serum vitamin B-12 and folate levels in IHD patients were significantly lower than in the control group (p = 0.001). Conclusions: It was determined that serum ghrelin levels increased in ischaemic heart disease patients, while serum levels of obestatin decreased. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|