Direct Compression Tablet Containing 99% Active Ingredient-A Tale of Spherical Crystallization
| Autor: | Changquan Calvin Sun, Aktham Aburub, Hongbo Chen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Active ingredient
Materials science Coumaric Acids Manufacturing process Diffusion Drug Compounding Pharmaceutical Science 02 engineering and technology 021001 nanoscience & nanotechnology Compression (physics) 030226 pharmacology & pharmacy Dilution law.invention Solvent Excipients 03 medical and health sciences 0302 clinical medicine Chemical engineering law Particle-size distribution Crystallization Powders 0210 nano-technology Tablets |
| Zdroj: | Journal of pharmaceutical sciences. 108(4) |
| ISSN: | 1520-6017 |
| Popis: | Direct compression (DC) is the easiest and most cost-effective process for tablet manufacturing, because it only involves blending and compression. However, active pharmaceutical ingredients generally exhibit poor mechanical and micromeritic properties, which necessitate dilution and the use of high percentage of excipients to enable a robust DC manufacturing process. Consequently, drug loading in DC tablets is usually low (typically |
| Databáze: | OpenAIRE |
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