Antibiotic Cycling Reverts Extensive Drug Resistance in Burkholderia multivorans
| Autor: | S K Harrison, Todd R. Steck, Logan G Kavanaugh, J N Flanagan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.drug_class
Burkholderia Antibiotics Drug Resistance Microbial Sensitivity Tests Biology Meropenem Cystic fibrosis Microbiology 03 medical and health sciences Antibiotic resistance medicine Humans Pharmacology (medical) Mechanisms of Action: Physiological Effects 030304 developmental biology Pharmacology 0303 health sciences 030306 microbiology Burkholderia cepacia complex Burkholderia multivorans Burkholderia Infections biology.organism_classification medicine.disease Phenotype Anti-Bacterial Agents Infectious Diseases Efflux medicine.drug |
| Zdroj: | Antimicrob Agents Chemother |
| ISSN: | 1098-6596 |
| Popis: | Antibiotic collateral sensitivity, in which acquired resistance to one drug leads to decreased resistance to a different drug, occurs in Burkholderia multivorans . Here, we observed that treatment of extensively drug-resistant variants from a cystic fibrosis (CF) sputum sample with either meropenem or sulfamethoxazole-trimethoprim, depending on past resistance phenotypes, resulted in increased sensitivity to five different classes of antibiotics. We further identified mutations, including putative resistance-nodulation-division efflux pump regulators and uncharacterized pumps, that may be involved in this phenotype in B. multivorans . |
| Databáze: | OpenAIRE |
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