Dopaminergic Modulation of Orofacial Mechanical Hypersensitivity Induced by Infraorbital Nerve Injury

Autor: Hiroshi Hanamoto, Hiroharu Maegawa, Hitoshi Niwa, Nayuka Usami, Chiho Kudo
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Dopamine
infraorbital nerve
6-hydroxydopamine
phosphorylated extracellular signal-regulated kinase (pERK)
lcsh:Chemistry
chemistry.chemical_compound
quinpirole
dopamine receptor
Phosphorylation
Extracellular Signal-Regulated MAP Kinases
lcsh:QH301-705.5
Spectroscopy
gamma-Aminobutyric Acid
Pain Measurement
GABAA receptor
A11 nucleus
Dopaminergic
Cranial Nerves
General Medicine
trigeminal spinal subnucleus caudalis
muscimol
Computer Science Applications
Spinal Cord
Hyperalgesia
Neuropathic pain
psychological phenomena and processes
medicine.drug
Agonist
Pain Threshold
medicine.medical_specialty
animal structures
medicine.drug_class
Hypothalamus
Catalysis
Article
Inorganic Chemistry
Infraorbital nerve
Quinpirole
Dopamine receptor D2
Internal medicine
medicine
Animals
GABA-A Receptor Agonists
Physical and Theoretical Chemistry
Rats
Wistar
Oxidopamine
Molecular Biology
chronic constriction injury
Facial Nerve Injuries
business.industry
Receptors
Dopamine D2
Organic Chemistry
Rats
nervous system diseases
Endocrinology
Muscimol
chemistry
lcsh:Biology (General)
lcsh:QD1-999
Neuralgia
business
Zdroj: International Journal of Molecular Sciences
Volume 21
Issue 6
International Journal of Molecular Sciences, Vol 21, Iss 6, p 1945 (2020)
ISSN: 1422-0067
DOI: 10.3390/ijms21061945
Popis: While the descending dopaminergic control system is not fully understood, it is reported that the hypothalamic A11 nucleus is its principle source. To better understand the impact of this system, particularly the A11 nucleus, on neuropathic pain, we created a chronic constriction injury model of the infraorbital nerve (ION-CCI) in rats. ION-CCI rats received intraperitoneal administrations of quinpirole (a dopamine D2 receptor agonist). ION-CCI rats received microinjections of quinpirole, muscimol [a gamma-aminobutyric acid type A (GABAA) receptor agonist], or neurotoxin 6-hydroxydopamine (6-OHDA) into the A11 nucleus. A von Frey filament was used as a mechanical stimulus on the maxillary whisker pad skin
behavioral and immunohistochemical responses to the stimulation were assessed. After intraperitoneal administration of quinpirole and microinjection of quinpirole or muscimol, ION-CCI rats showed an increase in head-withdrawal thresholds and a decrease in the number of phosphorylated extracellular signal-regulated kinase (pERK) immunoreactive (pERK-IR) cells in the superficial layers of the trigeminal spinal subnucleus caudalis (Vc). Following 6-OHDA microinjection, ION-CCI rats showed a decrease in head-withdrawal thresholds and an increase in the number of pERK-IR cells in the Vc. Our findings suggest the descending dopaminergic control system is involved in the modulation of trigeminal neuropathic pain.
Databáze: OpenAIRE
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