Non-invasive brain stimulation and computational models in post-stroke aphasic patients: single session of transcranial magnetic stimulation and transcranial direct current stimulation. A randomized clinical trial
| Autor: | Paulo S. Boggio, Ana Paula Machado Goyano Mac-Kay, Rubens José Gagliardi, Marom Bikson, Yu Huang, Marcel Simis, Dennis Q. Truong, Vitor Serafim, Vitor Breseghello Cavenaghi, Michele Devido dos Santos, Felipe Fregni, Alexandre Venturi |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment lcsh:Medicine Stimulation Context (language use) Transcranial Direct Current Stimulation 050105 experimental psychology law.invention Young Adult 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Double-Blind Method Randomized controlled trial law medicine Aphasia Humans 0501 psychology and cognitive sciences Prospective Studies Stroke Aged Speech disorders Transcranial direct-current stimulation business.industry lcsh:R 05 social sciences Stroke Rehabilitation General Medicine Middle Aged medicine.disease Transcranial Magnetic Stimulation Neuromodulation (medicine) Transcranial magnetic stimulation Treatment Outcome Brain stimulation Physical therapy Female Transcranial direct current stimulation business 030217 neurology & neurosurgery |
| Zdroj: | Sao Paulo Medical Journal v.135 n.5 2017 São Paulo medical journal Associação Paulista de Medicina instacron:APM Sao Paulo Medical Journal, Volume: 135, Issue: 5, Pages: 475-480, Published: 06 NOV 2017 Sao Paulo Medical Journal, Issue: ahead, Published: 06 NOV 2017 São Paulo Medical Journal, Iss 0 (2017) |
| Popis: | CONTEXT AND OBJECTIVE: Patients undergoing the same neuromodulation protocol may present different responses. Computational models may help in understanding such differences. The aims of this study were, firstly, to compare the performance of aphasic patients in naming tasks before and after one session of transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS) and sham, and analyze the results between these neuromodulation techniques; and secondly, through computational model on the cortex and surrounding tissues, to assess current flow distribution and responses among patients who received tDCS and presented different levels of results from naming tasks. DESIGN AND SETTING: Prospective, descriptive, qualitative and quantitative, double blind, randomized and placebo-controlled study conducted at Faculdade de Ciências Médicas da Santa Casa de São Paulo. METHODS: Patients with aphasia received one session of tDCS, TMS or sham stimulation. The time taken to name pictures and the response time were evaluated before and after neuromodulation. Selected patients from the first intervention underwent a computational model stimulation procedure that simulated tDCS. RESULTS: The results did not indicate any statistically significant differences from before to after the stimulation.The computational models showed different current flow distributions. CONCLUSIONS: The present study did not show any statistically significant difference between tDCS, TMS and sham stimulation regarding naming tasks. The patients’responses to the computational model showed different patterns of current distribution. |
| Databáze: | OpenAIRE |
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