Hormone replacement therapy lowers plasma Lp(a) concentrations. Comparison of cyclic transdermal and continuous estrogen-progestin regimens
| Autor: | Christian Ehnholm, Marja-Riitta Taskinen, M. Björn, S. Lahdenperä, T. Pyörälä, H. Luotola, J. Puolakka, J. Kääriäinen |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class medicine.medical_treatment Administration Oral Medroxyprogesterone Acetate 030204 cardiovascular system & hematology Administration Cutaneous 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans 030212 general & internal medicine Hormone replacement therapy Transdermal Chemotherapy biology Estradiol Progesterone Congeners business.industry Estrogen Replacement Therapy Lipoprotein(a) Middle Aged medicine.disease 3. Good health Menopause Postmenopause Drug Combinations Norethindrone Acetate Endocrinology Estrogen Cardiovascular Diseases biology.protein Female Norethindrone Cardiology and Cardiovascular Medicine business Lipoproteins HDL Progestin Lipoprotein |
| Zdroj: | Arteriosclerosis, thrombosis, and vascular biology. 16(10) |
| ISSN: | 1079-5642 |
| Popis: | To study the responses of serum lipoproteins, apoproteins (apo's), and lipoprotein(a) (Lp[a]) to two frequently used hormone replacement therapies (HRTs), 120 postmenopausal women were randomly allocated to receive either transdermal therapy consisting of 28-day cycles with patches that delivered 17β-estradiol (50 μg/d) combined with cyclic oral medroxyprogesterone acetate (10 mg/d for 12 days per cycle) or continuous oral 17β-estradiol (2 mg/d) together with norethisterone acetate (1 mg/d) for 12 months. Blood samples were taken before and at 6 and 12 months of HRT. Concentrations of serum total, low density lipoprotein (LDL) and high density lipoprotein (HDL) cholesterol decreased by 14% ( P P P P P P P P r =.96, P r =.88, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|