Effects of periodontal ligament stem cell‐derived exosomes on osteoblastic proliferation, migration, differentiation, apoptosis, and signaling pathways

Autor: Qian Lan, Xin Xiao, Xueting Bi, Yangcong Gu, Yilong Ai
Rok vydání: 2022
Předmět:
Zdroj: Oral Diseases.
ISSN: 1601-0825
1354-523X
DOI: 10.1111/odi.14375
Popis: Periodontitis is characterized by alveolar bone injury and absorption, with high incidence and poor treatment effect. Proliferation, migration, differentiation and apoptosis of osteoblasts are identified as key factors during the regeneration of alveolar bone tissue processes. Periodontal ligament stem cells (PDLSCs) have been proved to be a possible candidate for the treatment of periodontitis due to its multiple advantages, such as increasing the regenerative capacity of bone tissue. However, the effect of exosomes derived from PDLSCs (PDLSC-Exo) on osteoblasts remains to be further studied.In this work, cell proliferation, migration, osteogenic differentiation, and HWe found that PDLSC-Exo are capable of promoting hFOB1.19 cell proliferation, migration and osteogenic differentiation, inhibiting HThese results suggest that PDLSC-Exo may be a promising therapeutic for osteoblastic damage.
Databáze: OpenAIRE
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