Diagnosis and outcomes of pregnant women with Zika virus infection in two municipalities of Risaralda, Colombia: Second report of the ZIKERNCOL study
| Autor: | Juan Daniel Castrillón-Spitia, Jaime A. Cardona-Ospina, Fredy Alexander Tabares-Villa, Alfonso J. Rodriguez-Morales, José J. Londoño, David R. Murillo-García, Valeria Ramírez-Jaramillo, Hector D. Bedoya-Rendón, Valentina Henao-SanMartin, Javier A. Gaviria, Gloria María González-Moreno, Javier de Jesús Cárdenas-Pérez, Adriana M. Trujillo, German Eduardo Rueda-Merchán, Marta Liliana Buitrago-Cañas, Estefania Morales-Jiménez, Johana Andrea Herrera-Soto, Matthew H. Collins, Sandra X. Olaya, Valentina Ramírez-Zapata, Guillermo J. Lagos-Grisales, Juan Carlos Sepúlveda-Arias, Alejandra López-Villegas |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty Microcephaly Adolescent 030231 tropical medicine Colombia Antibodies Viral medicine.disease_cause Asymptomatic Dengue fever Zika virus Cohort Studies Dengue Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Humans Travel medicine 030212 general & internal medicine Chikungunya Pregnancy Complications Infectious Rubella Retrospective Studies biology Zika Virus Infection Obstetrics business.industry Infant Newborn Public Health Environmental and Occupational Health medicine.disease biology.organism_classification Infectious Diseases Immunoglobulin G Cohort Chikungunya Fever Female medicine.symptom business Toxoplasmosis |
| Zdroj: | Travel Medicine and Infectious Disease. 25:20-25 |
| ISSN: | 1477-8939 |
| DOI: | 10.1016/j.tmaid.2018.06.006 |
| Popis: | Background Zika virus (ZIKV) infection has emerged as a significant threat for pregnant women and newborns in populations living in or visiting Latin America. We previously reported a preliminary analysis in Sucre, Colombia, as the first group of pregnant women with RT-PCR-confirmed ZIKV ( ZIK a en E mbarazadas y R ecien N acidos en COL ombia, ZIKERNCOL). Methods In this second report, findings of the first 86 pregnant women from La Virginia and Dosquebradas (municipalities), Risaralda, Colombia, with RT-PCR-confirmed ZIKV infection are reported. Clinical, demographical and obstetrical findings are described. Results All women reported ZIKV symptoms during pregnancy: 79.1% rash, 55.8% fever, among others. In addition to ZIKV, RT-PCR was positive for dengue in 18.6%; 45.3% Dengue IgM+; 5.8% RT-PCR positive for chikungunya; 3.6% Chikungunya IgM+. STORCH screening in mother: 11.6% IgG + anti-Toxoplasma gondii, 6% IgG + anti-rubella, 4.7% IgG + CMV. The rest of STORCH tests were negative. Microcephaly was observed in 2.4% of the newborns. No calcifications or other CNS alterations were detected. One newborn had cleft palate and one had bilateral renal ectopy. Conclusions The rate of microcephaly in our cohort was consistent with other studies. Pregnant women in endemic areas should be followed and tested according to standard protocols, and asymptomatic ZIKV infection should be considered. Long-term follow-up of children is required in the congenital Zika syndrome (CZS) assessment. |
| Databáze: | OpenAIRE |
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