Desmosomes in Human Disease

Autor: Nicole A. Najor
Rok vydání: 2018
Předmět:
Zdroj: Annual Review of Pathology: Mechanisms of Disease. 13:51-70
ISSN: 1553-4014
1553-4006
Popis: Tissue integrity is crucial for maintaining the homeostasis of living organisms. Abnormalities that affect sites of cell-cell contact can cause a variety of debilitating disorders. The desmosome is an essential cell-cell junctional protein complex in tissues that undergo stress, and it orchestrates intracellular signal transduction. Desmosome assembly and junctional integrity are required to maintain the overall homeostasis of a tissue, organ, and organism. This review discusses the desmosome and the human diseases associated with its disruption.
Databáze: OpenAIRE