Desmosomes in Human Disease
| Autor: | Nicole A. Najor |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Armadillo Proteins Desmosomes Biology Pathology and Forensic Medicine Cell biology Intracellular signal transduction 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure Human disease Desmosome Desmosome assembly medicine Humans Desmosomal Cadherins Organism Homeostasis |
| Zdroj: | Annual Review of Pathology: Mechanisms of Disease. 13:51-70 |
| ISSN: | 1553-4014 1553-4006 |
| Popis: | Tissue integrity is crucial for maintaining the homeostasis of living organisms. Abnormalities that affect sites of cell-cell contact can cause a variety of debilitating disorders. The desmosome is an essential cell-cell junctional protein complex in tissues that undergo stress, and it orchestrates intracellular signal transduction. Desmosome assembly and junctional integrity are required to maintain the overall homeostasis of a tissue, organ, and organism. This review discusses the desmosome and the human diseases associated with its disruption. |
| Databáze: | OpenAIRE |
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