Increased Prevalence of Minor Physical Anomalies Among the Healthy First-Degree Relatives of Bipolar I Patients - Results With the Méhes Scale
| Autor: | María Rosa Simón, Márton Kovács, Róbert Herold, Tamás Tényi, Viktor Vörös, Márton Herold, Tímea Csulak, Györgyi Csábi, Ákos Tóth, Sára Jeges, Andras Hajnal |
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| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Bipolar I disorder RC435-571 03 medical and health sciences 0302 clinical medicine psychotic disorders Medicine Minor physical anomalies Bipolar disorder First-degree relatives Normal control Psychiatry bipolar disorder neurodevelopment business.industry somatic markers Brief Research Report medicine.disease Trunk 030227 psychiatry endophenotype High arched palate Psychiatry and Mental health Endophenotype business 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Psychiatry Frontiers in Psychiatry, Vol 12 (2021) |
| ISSN: | 1664-0640 |
| Popis: | Minor physical anomalies are somatic markers of aberrant neurodevelopment, so the higher prevalence of these signs among the relatives of bipolar I patients can confirm minor physical anomalies as endophenotypes. The aim of the study was to evaluate the prevalence of minor physical anomalies in first-degree healthy relatives of patients with bipolar I disorder compared to normal control subjects. Using a list of 57 minor physical anomalies (the Méhes Scale), 20 first-degree unaffected relatives of patients with the diagnosis of bipolar I disorder and as a comparison 20 matched normal control subjects were examined. Minor physical anomalies were more common in the ear, head, mouth and trunk regions among the relatives of bipolar I patients compared to normal controls. By the differentiation of minor malformations and phenogenetic variants, we have found that both minor malformations and phenogenetic variants were more common among the relatives of bipolar I patients compared to the control group, while individual analyses showed, that one minor malformation (sole crease) and one phenogenetic variant (high arched palate) were more prevalent in the relative group. This is the first report in literature on the increased prevalence of minor physical anomalies among the first-degree unaffected relatives of bipolar I patients. The study support the concept, that minor physical anomalies can be endophenotypic markers of bipolar I affective disorder. |
| Databáze: | OpenAIRE |
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