The Role of Inflammatory, Anti-Inflammatory, and Regulatory Cytokines in Patients Infected with Cutaneous Leishmaniasis in Amazonas State, Brazil

Autor: Luanda de Paula Figueira, Maricleide de Farias Naiff, Adriana Malheiro, Marcelo Ramalho-Ortigao, Thaís Tibery Espir, Antonia Maria Ramos Franco, Allyson Guimarães Costa
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
Skin Leishmaniasis
Physiology
Protein Expression
Immunology and Allergy
Antiinflammatory Activity
Interferon gamma
Leishmania guyanensis
Autacoid
Clinical Comparative Study
Leishmania
biology
Interleukin-17
General Medicine
Middle Aged
Classification
Flow Cytometry
Interleukin-10
Interleukin 10
Blood
Cytokines
Tumor necrosis factor alpha
Female
Interleukin 17
Inflammation Mediators
Brazil
Research Article
medicine.drug
Human
Interleukin 2
Adult
lcsh:Immunologic diseases. Allergy
Article Subject
Adolescent
Immunology
Species Difference
Leishmaniasis
Cutaneous
Leishmania Guyanensis
Host-parasite Interactions
Host-Parasite Interactions
Young Adult
Interferon-gamma
Cutaneous leishmaniasis
Species Specificity
Leishmania Naiffi
medicine
Humans
Controlled Study
Cytokine
Gamma Interferon
Interleukin-6
Tumor Necrosis Factor-alpha
Brasil
medicine.disease
biology.organism_classification
Nonhuman
Protein Blood Level
Host Parasite Interaction
Interleukin-2
Parasitology
Interleukin-4
lcsh:RC581-607
Zdroj: Journal of Immunology Research, Vol 2014 (2014)
Repositório Institucional do INPA
Instituto Nacional de Pesquisas da Amazônia (INPA)
instacron:INPA
Journal of Immunology Research
ISSN: 2314-7156
2314-8861
Popis: The authors discuss in this paper the role of inflammatory, anti-inflammatory, and regulatory cytokines in patients infected with different species ofLeishmaniain Amazonas State, Brazil. A comparative analysis was made of serum concentrations of these cytokines in the peripheral blood of 33 patients infected with cutaneous leishmaniasis. The isolates were identified asLeishmania guyanensis,L. naiffi, andL. amazonensis. Most (64%) of the patients were male ranging in age from 18 to 58 years. Protein expression profiles of IL-2, IL-4, IL-6, IL-10, IFN-γ, TNF-α, and IL-17 cytokines were shown to vary significantly between infected and noninfected (control group) individuals and according to theLeishmaniaspecies. Infection caused byL. guyanensisaccounted for 73% of the cases and patients with this parasite also showed higher concentrations of IL-2, IFN-γ, IL-4, and IL-17 when compared to infection byL. amazonensis. Patients with infection caused byL. naiffishowed higher concentration of the cytokines analyzed when compared to uninfected patients; however, there was no statistically significant difference with the other species analyzed.
Databáze: OpenAIRE
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