TNFR1-383 A˃C polymorphism association with clinical manifestations in primary Sjögren’s syndrome patients
| Autor: | Claudia Azucena Palafox-Sánchez, G Orozco-Barocio, E. Oregon-Romero, Rosa E. Navarro-Hernandez, J.F. Muñoz-Valle, Fletes-Rayas Al |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Gastroenterology Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Gene Frequency Rheumatoid Factor Internal medicine Genetics medicine Humans Rheumatoid factor Allele Molecular Biology Allele frequency Aged 030203 arthritis & rheumatology Autoimmune disease Polymorphism Genetic biology business.industry C-reactive protein Case-control study General Medicine Middle Aged respiratory system medicine.disease C-Reactive Protein Sjogren's Syndrome Receptors Tumor Necrosis Factor Type I Case-Control Studies Rheumatoid arthritis biology.protein Female business 030215 immunology |
| Zdroj: | Genetics and Molecular Research. 15 |
| ISSN: | 1676-5680 |
| DOI: | 10.4238/gmr.15024177 |
| Popis: | Primary Sjögren's syndrome is an autoimmune disease affecting the function of exocrine glands. Tumor necrosis factor receptor-1 (TNFR1) is involved in apoptosis through extrinsic pathway initiation. The level of soluble TNFR1 is reported increased in rheumatoid arthritis, systemic lupus erythematosus, and primary Sjögren's syndrome patients. The TNFR1 gene contains a polymorphism that replaced an adenine with a cytosine at the -383 in promoter region position. The TNFR1-383 A˃C polymorphism has been associated with rheumatic diseases. We examined the association between the TNFR1-383 A˃C polymorphism and TNFR1 soluble (sTNFR1) levels and laboratory and clinical characteristics in primary Sjögren's syndrome patients. Eighty-two patients with primary Sjögren's syndrome classified using the American-European criteria and 84 healthy subjects were studied. Sjögren's Syndrome Disease Activity Index (SSDAI) and Sjögren's Syndrome Disease Damage Index were performed for all patients. Genotypic and allelic frequencies were similar in both groups (P = 0.317 and P = 0.329, respectively). sTNFR1 levels were similar in patients and healthy subjects (P = 0.051). High levels of C-reactive protein (P = 0.045) and rheumatoid factor (P = 0.040) in patients with the A˃C genotype were observed. In these patients, the SSDAI score was higher than in A˃A genotype carriers (P = 0.045). This is the first study that to examine the TNFR1-383 A˃C polymorphism in primary Sjögren's syndrome patients. Clinical parameters and SSDAI index were associated in A˃C genotype carriers. However, further studies with a larger sample are necessary to verify the association between primary Sjögren's syndrome and the TNFR1-383 A˃C polymorphism. |
| Databáze: | OpenAIRE |
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