Pathologic effects of testosterone deprivation
| Autor: | Preston C. Sprenkle, Harry Fisch |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Oncology medicine.medical_specialty Antineoplastic Agents Hormonal Libido Sexual Behavior Urology Endocrine System Risk Assessment Androgen deprivation therapy Prostate cancer Cognition Risk Factors Internal medicine medicine Humans Adverse effect Musculoskeletal System Testosterone Metabolic Syndrome business.industry Prostatic Neoplasms Androgen Antagonists medicine.disease Affect Hot Flashes Metabolic syndrome Energy Metabolism business Orchiectomy |
| Zdroj: | Current Opinion in Urology. 17:424-430 |
| ISSN: | 0963-0643 |
| Popis: | Androgen deprivation therapy remains the cornerstone of treatment for advanced prostate cancer. There are significant adverse effects associated with prolonged androgen deprivation therapy, with recent findings associating it with the metabolic syndrome and its associated health risks.A review of the adverse pathologic effects of testosterone deprivation is performed. Recent findings associate androgen deprivation therapy with endocrine and metabolic disarray, specifically the metabolic syndrome, resulting in increased rates of diabetes and myocardial infarction in patients on testosterone deprivation.The increased incidence of the metabolic syndrome in patients receiving androgen deprivation therapy and the associated morbidity and possibly mortality require significant investigation into alternatives to complete testosterone deprivation and ways to counteract these adverse effects. |
| Databáze: | OpenAIRE |
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