A three course menu for ILC and bystander T cell activation
| Autor: | Jakob von Moltke, John W. McGinty |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cell type T cell Immunology Biology stat Article 03 medical and health sciences 0302 clinical medicine medicine Bystander effect Immunology and Allergy Animals Humans Lymphocytes skin and connective tissue diseases Transcription factor Effector Innate lymphoid cell T-Lymphocytes Helper-Inducer Immunity Innate Chromatin body regions 030104 developmental biology medicine.anatomical_structure Neuroscience 030215 immunology |
| Zdroj: | Curr Opin Immunol |
| ISSN: | 1879-0372 |
| Popis: | The varied list of agonists that activate innate lymphoid cells (ILCs) continues to grow, but whether and how these signals interact is not well defined, especially in vivo. ILC subsets share master transcription factors, chromatin landscapes, and effector cytokines with their corresponding T helper (Th) cell subsets. Here we discuss how studies of these two cell types can inform each other. Specifically, we outline a framework in which ILC agonists are grouped by the transcription factors they activate. Optimal ILC activation requires at least three items from a 'menu' of non-redundant signals that collectively replicate the STAT and TCR signaling that drives effector Th cell function. This conceptual model may also apply to TCR-independent 'bystander' activation of Th cells. |
| Databáze: | OpenAIRE |
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