Transdermal Delivery of Snakehead Fish (Ophiocephalus striatus) Nanoemulgel Containing Hydrophobic Powder for Burn Wound
| Autor: | Prisca Safriani Wicita, Robert Tungadi, Widy Susanty, Elvira Pido |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
nanoemulgel
nanoemulsion Pharmaceutical Science lcsh:RS1-441 02 engineering and technology 030226 pharmacology & pharmacy Snakehead lcsh:Pharmacy and materia medica 03 medical and health sciences 0302 clinical medicine Pulmonary surfactant In vivo Zeta potential General Pharmacology Toxicology and Pharmaceutics Transdermal Burn wound Chromatography biology Chemistry burn wound Permeation 021001 nanoscience & nanotechnology biology.organism_classification transdermal snakehead fish powder 0210 nano-technology Ex vivo |
| Zdroj: | Pharmaceutical Sciences, Vol 24, Iss 4, Pp 313-323 (2018) |
| ISSN: | 2383-2886 |
| Popis: | Background: The aim of the present study was to characterize and evaluate the nanoemulgel (NEG) of snakehead fish powder (SFP), as a transdermal delivery system for poorly water soluble drug, in order to conquer the inconveniences related to its oral conveyance. Methods: Diverse nanoemulsion components (oil, surfactant, and co-surfactant) were chosen based on solvency and emulsification capacity. SFP loaded nanoemulsion which tested by stress-stability testing was carried out for all formulations and those that passed these tests were characterized for mean droplet size, polydispersity index (PDI), zeta potential, pH, viscosity, and transmittance. After that, this was continued by permeation studies using snake skin in vitro and rabbit skin in vivo studies i.e. skin irritation study and the effectiveness test. Results: Mean droplet size and zeta potential of the optimized nanoemulsion (NE4) were found to be 98.6 ± 0.93 nm (polydispersity index, PDI = 0.1 ± 0.20) and -57.5 ± 0.3 mV respectively. Optimized nanoemulsion was converted into nanoemulgel with 1.5% w/v of gelling agent (HPMC) and evaluated for pH, viscosity, spreadability, and extrudability measurement. Ex vivo transdermal permeation value for SFP through snake skin as membrane from NEG1, NEG2, NEG3 and marketed SFP cream showed results of 55.65 ± 0.93%, 56.14 ± 0.70%, 66.75 ± 1.03% and 49.80 ± 3.42% respectively in 3 hours. Moreover, all the treatment group did not show skin irritation of each group. The effect of burn wound healing of NEG3 showed a significant (P |
| Databáze: | OpenAIRE |
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