First-trimester maternal serum schwangerschafts protein 1 (SP1) in pregnancies associated with chromosomal anomalies
| Autor: | Bruno Brambati, T. Chard, J. G. Grudzinskas, M. C. M. Macintosh |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
medicine.medical_specialty Down syndrome Aneuploidy Chorionic villus sampling Chromosome Disorders Pregnancy Proteins Biology Pregnancy medicine Humans Mass Screening Genetics (clinical) Chromosome Aberrations Gynecology Fetus medicine.diagnostic_test Obstetrics Obstetrics and Gynecology Middle Aged medicine.disease Pregnancy Trimester First medicine.anatomical_structure Chorionic Villi Sampling Karyotyping Chorionic villi Gestation Female Trisomy |
| Zdroj: | Prenatal Diagnosis. 13:563-568 |
| ISSN: | 1097-0223 0197-3851 |
| DOI: | 10.1002/pd.1970130705 |
| Popis: | The relationship between first-trimester maternal serum Schwangerschafts protein 1 (SP1) and the karyotype of the pregnancy was examined in 692 women who underwent chorionic villus biopsy at 6-12 weeks. There were 30 pregnancies with abnormal karyotypes, consisting of 14 Down's syndrome (DS), eight trisomy 18, and eight other anomalies, two of which were mosaics. The normal ranges and medians for gestation were defined from the 662 cases in which the karyotype was normal. The median SP1 (0.5 MOM) of the abnormal group was significantly lower than that of the normal group (1.0 MOM). This relationship was maintained for the DS pregnancies (0.4 MOM) and for anomalies other than trisomy 18 (0.43 MOM) but not trisomy 18 (1.1 MOM). It is possible that the use of SP1 as a screening test for chromosome anomalies in the first trimester could have a 43 per cent detection rate for a 5 per cent false-positive rate. |
| Databáze: | OpenAIRE |
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