Dose-finding study of intensive weekly alternating schedule of docetaxel, 5-fluorouracil, and oxaliplatin, FD/FOx regimen, in metastatic gastric cancer
| Autor: | Gemma Bruera, Silvia Massacese, Eugenio Ciacco, Enrico Ricevuto, Antonio Galvano, Antonio Russo, Stefano Guadagni, Giuseppe Calvisi, Antonella Dal Mas |
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| Přispěvatelé: | Bruera, Gemma, Massacese, Silvia, Galvano, Antonio, Dal Mas, Antonella, Guadagni, Stefano, Calvisi, Giuseppe, Ciacco, Eugenio, Russo, Antonio, Ricevuto, Enrico |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Settore MED/06 - Oncologia Medica Docetaxel Neutropenia metastatic gastric cancer And oxaliplatin 03 medical and health sciences 0302 clinical medicine docetaxel 5-fluorouracil and oxaliplatin Internal medicine medicine Mucositis dose-finding study 5-fluorouracil Dose-finding study FD/FOx intensive regimen First-line triplet chemotherapy Metastatic gastric cancer Oncology Hypoalbuminemia business.industry medicine.disease Oxaliplatin Regimen 030104 developmental biology Fluorouracil 030220 oncology & carcinogenesis first-line triplet chemotherapy Cohort business medicine.drug Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Gemma Bruera 1, 2 , Silvia Massacese 3 , Antonio Galvano 4 , Antonella Dal Mas 5 , Stefano Guadagni 6, 2 , Giuseppe Calvisi 5 , Eugenio Ciacco 3 , Antonio Russo 4 , Enrico Ricevuto 1, 2 , on behalf of Oncology Network ASL1 Abruzzo, Italy 1 Oncology Territorial Care, S. Salvatore Hospital, Oncology Network ASL1 Abruzzo, University of L'Aquila, L'Aquila, Italy 2 Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy 3 Pharmacy Unit, S. Salvatore Hospital, Oncology Network ASL1 Abruzzo, L’Aquila, Italy 4 Medical Oncology, Department of Surgical, Oncological and Stomatological Sciences, University of Palermo, Palermo, Italy 5 Pathology, S. Salvatore Hospital, Oncology Network ASL1 Abruzzo, L'Aquila, Italy 6 Universitary General Surgery, S. Salvatore Hospital, Oncology Network ASL1 Abruzzo, University of L'Aquila, L'Aquila, Italy Correspondence to: Antonio Russo, email: antonio.russo@usa.net Keywords: docetaxel, 5-fluorouracil, and oxaliplatin; FD/FOx intensive regimen; dose-finding study; first-line triplet chemotherapy; metastatic gastric cancer Received: January 24, 2018 Accepted: March 07, 2018 Published: April 17, 2018 ABSTRACT Introduction: Proper administration timing, dose-intensity, efficacy/toxicity ratio of triplet docetaxel (DTX), 5-fluorouracil (5-FU), and oxaliplatin (OXP) should be improved to safely perform three-drugs intensive first line in advanced gastric cancer (GC). This dose-finding study investigated recommended 5-FU and OXP doses, safety of triplet regimen and preliminary activity. Methods: Schedule: 12h-timed-flat-infusion 5-FU 700-1000 mg/m 2 /d 1-2, 8-9, 15-16, 22-23, with 100 mg/m 2 /d increase for dose level; DTX 50 mg/m 2 d 1, 15 fixed dose, OXP at three increasing dose-levels 60-70-80 mg/m 2 d 8, 22, every 4 weeks. Intra- and inter-patients dose-escalation was planned. Results: Ten fit |
| Databáze: | OpenAIRE |
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