Pharmaceutical evaluation of genistein-loaded pluronic micelles for oral delivery
| Autor: | Tae Jong Im, Kyoung Hoon Kang, Kyoung Wook Ha, Myung Joo Kang, Yong Min Kim, Suk Hyung Kwon, Jaehwi Lee, Young Mi Park, Jung Yun Chang, Young Wook Choi, Jin Seo Huh, Sun Young Kim, Sangkil Lee |
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| Rok vydání: | 2007 |
| Předmět: |
Drug
Male media_common.quotation_subject Genistein Administration Oral Poloxamer Micelle Rats Sprague-Dawley chemistry.chemical_compound Oral administration Drug Discovery Copolymer Animals heterocyclic compounds Solubility Particle Size Micelles media_common Chromatography Organic Chemistry food and beverages Hydrogen-Ion Concentration Bioavailability Rats chemistry Molecular Medicine |
| Zdroj: | Archives of pharmacal research. 30(9) |
| ISSN: | 0253-6269 |
| Popis: | The purpose of the present study was to determine whether Pluronic F127 polymeric micelles could improve the oral bioavailability of a poor water-soluble drug, such as genistein. Genistein is a phytoestrogen that has estrogenic activity. F127 triblock copolymer consists of PEO100-PPO65-PEO100. Genistein was incorporated in the Pluronic F127 polymeric micelles by a solid dispersion method. The genistein release of genistein-loaded polymeric micelles was studied in vitro (in pH 1.2 and pH 6.8). And the oral bioavailabilities of genistein powder and genistein-loaded micelles were estimated at a dose of 4.0 mg/kg as genistein in rats. Drug loading amount and drug loading efficiency were 11.18% and 97.41%, respectively. The average size of the genistein-loaded polymeric micelles was 27.76 nm. And genistein release of the genistein-loaded polymeric micelles in vitro was 58% (pH 1.2) and 82% (pH 6.8). The bioavailability of genistein-loaded polymeric micelles was better than genistein powder. Consequently, Pluronic F127 polymeric micelles are an effective delivery system for the oral administration of genistein. |
| Databáze: | OpenAIRE |
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