Regulation of transcription by the Epstein–Barr virus nuclear antigen EBNA 2
| Autor: | Helen M. Webb, Michelle J. West, Richard D. Palermo, Andrea Gunnell |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Herpesvirus 4
Human Transcription Genetic General transcription factor Viral protein viruses Biology medicine.disease_cause Antiviral Agents Biochemistry Epstein–Barr virus Molecular biology Virus Viral Proteins chemistry.chemical_compound Epstein-Barr Virus Nuclear Antigens Gene Expression Regulation chemistry Transcription (biology) hemic and lymphatic diseases RNA polymerase medicine Humans Cyclin-dependent kinase 9 Phosphorylation Transcription factor |
| Zdroj: | Biochemical Society Transactions. 36:625-628 |
| ISSN: | 1470-8752 0300-5127 |
| DOI: | 10.1042/bst0360625 |
| Popis: | The EBNA 2 (Epstein–Barr nuclear antigen 2) transcription factor is essential for B-cell transformation by the cancer-associated EBV (Epstein–Barr virus) and for the continuous proliferation of infected cells. EBNA 2 activates transcription from the viral Cp (C promoter) during infection to generate the 120 kb transcript that encodes all nuclear antigens required for immortalization by EBV. EBNA 2 contains an acidic activation domain and can interact with a number of general transcription factors and co-activators. It is now becoming clear, however, that the regulation of transcription elongation in addition to initiation by EBNA 2, at least in part through CDK9 (cyclin-dependent kinase 9)-dependent phosphorylation of the RNA polymerase C-terminal domain, is likely to play a crucial role in the mechanism of action of this key viral protein. |
| Databáze: | OpenAIRE |
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