Acetylcysteine reduces plasma homocysteine concentration and improves pulse pressure and endothelial function in patients with end-stage renal failure
| Autor: | Martin Tepel, Reiner Riezler, Joachim Beige, Christiane Rinder, Alexandra Scholze, Walter Zidek |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Homocysteine Endothelium medicine.medical_treatment Blood Pressure Antioxidants Acetylcysteine chemistry.chemical_compound Renal Dialysis Physiology (medical) Internal medicine Medicine Humans Aged Cross-Over Studies business.industry medicine.disease Crossover study Pulse pressure Vasodilation Blood pressure Endocrinology medicine.anatomical_structure chemistry Cardiology Kidney Failure Chronic Female Hemodialysis Endothelium Vascular Cardiology and Cardiovascular Medicine business Kidney disease medicine.drug |
| Zdroj: | Scholze, A, Rinder, C, Beige, J, Riezler, R, Zidek, W & Tepel, M 2004, ' Acetylcysteine reduces plasma homocysteine concentration and improves pulse pressure and endothelial function in patients with end-stage renal failure ', Circulation, vol. 109, no. 3, pp. 369-74 . https://doi.org/10.1161/01.CIR.0000109492.65802.AD |
| ISSN: | 1524-4539 |
| DOI: | 10.1161/01.CIR.0000109492.65802.AD |
| Popis: | Background— Increased oxidative stress, elevated plasma homocysteine concentration, increased pulse pressure, and impaired endothelial function constitute risk factors for increased mortality in patients with end-stage renal failure. Methods and Results— We investigated the metabolic and hemodynamic effects of intravenous administration of acetylcysteine, a thiol-containing antioxidant, during a hemodialysis session in a prospective, randomized, placebo-controlled crossover study in 20 patients with end-stage renal failure. Under control conditions, a hemodialysis session reduced plasma homocysteine concentration to 58±22% predialysis (mean±SD), whereas in the presence of acetylcysteine, the plasma homocysteine concentration was significantly more reduced to 12±7% predialysis ( P Conclusions— Acetylcysteine-dependent increase of homocysteine removal during a hemodialysis session improves plasma homocysteine concentration, pulse pressure, and endothelial function in patients with end-stage renal failure. |
| Databáze: | OpenAIRE |
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