Trefoil factor family (TFF) peptides and cancer progression
| Autor: | Shahin Emami, Christelle M. Rodrigue, Samir Attoub, Christian Gespach, Erik Bruyneel, Christine Rivat, Nathalie Le Floch, Sylvie Rodrigues |
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| Rok vydání: | 2003 |
| Předmět: |
Trefoil Factors
Gastrointestinal tract Physiology business.industry Angiogenesis Cancer Inflammation medicine.disease Biochemistry Cellular and Molecular Neuroscience Endocrinology Apoptosis Neoplasms Immunology medicine Humans Neoplasm Invasiveness Signal transduction medicine.symptom business Peptides Proto-oncogene tyrosine-protein kinase Src Signal Transduction |
| Zdroj: | Peptides. 25(5) |
| ISSN: | 0196-9781 |
| Popis: | TFF peptides are involved in mucosal maintenance and repair through motogenic and antiapoptotic activities. These peptides are overexpressed during inflammatory processes and cancer progression. They also function as scatter factors, proinvasive and angiogenic agents. Such a divergence is related to the pathophysiological state of tissues submitted to persistent aggressive situations during digestive processes in the normal gastrointestinal tract, inflammatory and neoplastic diseases. In agreement with this model, TFF peptides are connected with multiple oncogenic pathways. As a consequence, the TFF signaling pathways may serve as potential targets in the control of chronic inflammation and progression of human solid tumors. |
| Databáze: | OpenAIRE |
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