UCH-L1 and UCH-L3 regulate the cancer stem cell-like properties through PI3 K/Akt signaling pathway in prostate cancer cells
| Autor: | Jung Hwa Kim, Yun Hwan Lim, Jae Eun Lee |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
uch-l1
Medicine (General) uch-l3 QH301-705.5 business.industry Articles pi3 k/akt signaling pathway urologic and male genital diseases medicine.disease General Biochemistry Genetics and Molecular Biology Prostate cancer R5-920 Cancer stem cell Pi3 k akt csc-like property medicine Cancer research Animal Science and Zoology Biology (General) Signal transduction business Research Article |
| Zdroj: | Animal Cells and Systems, Vol 25, Iss 5, Pp 312-322 (2021) Animal Cells and Systems article-version (VoR) Version of Record |
| ISSN: | 2151-2485 1976-8354 |
| DOI: | 10.1080/19768354.2021.1987320 |
| Popis: | Castration-resistant prostate cancer (CRPC) is a highly aggressive and advanced prostate cancer that is currently incurable with conventional therapies. The recurrence and chemotherapy-resistant properties of CRPC are attributed to prostate cancer stem cells (CSCs). On the other hand, the factors regulating the prostate CSC-like properties have not been studied extensively. Previously, ubiquitin C-terminal hydrolase-L1 (UCH-L1) and ubiquitin C-terminal hydrolase-L3 (UCH-L3) were reported to be involved in prostate cancer cell progression through the epithelial-to-mesenchymal transition (EMT) regulation. Here, the differential regulation on the CSC-like properties by UCH-L1 and UCH-L3 were identified in prostate cancer cells. The CSC-like characteristics, such as the expression of pluripotency markers, chemoresistance, and sphere-forming ability, were promoted by UCH-L1, whereas those were repressed by UCH-L3. Moreover, the modulation of CSC-like properties by UCH-L1 and UCH-L3 was through the PI3 K/Akt signaling pathway. The CSC-like properties induced by UCH-L1 overexpression or UCH-L3 depletion were suppressed by the PI3 K/Akt pathway inhibitor. In conclusion, UCH-L1 and UCH-L3 are novel regulators of the CSC-like properties and shed light on new therapeutic strategies to overcome CSCs in prostate cancers. |
| Databáze: | OpenAIRE |
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