Nivalenol, a main Fusarium toxin in dietary foods from high-risk areas of cancer of esophagus and gastric cardia in China, induced benign and malignant tumors in mice
| Autor: | Chu Chieh Hsia, Ze Yuan Wu, Zong Tang Sun, Yun Sian Li, Fan Zhang |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Fusarium Cancer Research medicine.medical_specialty Esophageal Neoplasms Flour medicine.disease_cause Zea mays Gastroenterology Chromosome aberration Mice Stomach Neoplasms Internal medicine Odds Ratio medicine Animals Humans Esophagus Stomach cancer Chromatography High Pressure Liquid Chromosome Aberrations Mice Inbred BALB C Papilloma biology Esophageal disease Toxin Carcinoma Temperature Cancer Cardia Hordeum Neoplasms Experimental General Medicine Mycotoxins Esophageal cancer medicine.disease biology.organism_classification Animal Feed Diet medicine.anatomical_structure Oncology Immunology Female Trichothecenes |
| Zdroj: | Oncology Reports. |
| ISSN: | 1791-2431 1021-335X |
| Popis: | This is the first report that a Fusarium toxin nivalenol (NIV) naturally existing at high levels in dietary food in high-risk areas of cancer of esophagus and gastric cardia in China induced benign and malignant tumors in mice. The levels of two Fusarium toxins, nivalenol and deoxynivalenol (DON) were quantitated using high performance liquid chromatography (HPLC) in a total of 97 samples of dietary wheat flour, barley and corn collected from families in two areas with high mortality rate of cancer of esophagus and gastric cardia (132/100,000), Linxian, Henan province and Cixiang, Hepei province, China. The mean level of NIV and DON in three dietary foods was 830+/-927 microg/kg (range 584-1,780 microg/kg) and 4,281+/-6,114 microg/kg (range 732-10,980 microg/kg) respectively. The highest mean level of NIV was 1,780+/-1,705 microg/kg found in barley from Linxian, that of DON was 10,980+/-10,139 microg/kg found in corn from Cixiang. NIV was undetectable in 2 samples of rice from USA. The mean levels of NIV in three main dietary foods in those two high-risk areas were estimated at 400 to 800-fold higher than that in the USA, where NIV was undetectable in dietary food, and the mortality rate of esophageal cancer is |
| Databáze: | OpenAIRE |
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