Inhibition of HIV replication in vitro by clinical immunosuppressants and chemotherapeutic agents
Autor: | Mark Spear, Yuntao Wu, Todd Hawley, Jia Guo |
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Rok vydání: | 2013 |
Předmět: |
medicine.medical_treatment
T cell Rev-CEM Short Report CD4 T cells Pharmacology Peripheral blood mononuclear cell General Biochemistry Genetics and Molecular Biology Mycophenolic acid 03 medical and health sciences 0302 clinical medicine medicine Chemotherapy Cytotoxicity 030304 developmental biology 0303 health sciences business.industry Cytarabine In vitro 3. Good health medicine.anatomical_structure HIV-1 Cyclosporine Stem cell business 030215 immunology medicine.drug |
Zdroj: | Cell & Bioscience |
ISSN: | 2045-3701 |
DOI: | 10.1186/2045-3701-3-22 |
Popis: | Background Recent studies have suggested that a functional cure for HIV-1 infection, purportedly resultant from allogeneic bone marrow transplantation, may be possible. Additionally, the first such patient was treated with whole-body irradiation, immunosuppressants, and the chemotherapeutic, cytarabine. However, the precise role of the coinciding medical interventions in diminishing detectable HIV reservoirs remains unstudied. Findings In this article, we demonstrate that the immunosuppressants, mycophenolic acid and cyclosporine, and the chemotherapeutic, cytarabine, are potent antiretroviral agents at clinically relevant dosages. These drugs strongly inhibit HIV-1 replication in a GFP indicator T cell line and peripheral blood mononuclear cells (PBMC). Conclusions Our study suggests that certain clinical immunosuppressants and chemotherapeutic agents may act combinatorially to inhibit HIV infection. Additionally, chemotherapy-mediated cytotoxicity may also affect the stability of viral reservoirs. Thus, further study is needed to examine potential therapeutic value of these interventions in patients. |
Databáze: | OpenAIRE |
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