Persistence of mild parkinsonism 4 months after liver transplantation in patients with preoperative minimal hepatic encephalopathy: a study on neuroradiological and blood manganese changes
| Autor: | François Vingerhoets, Pierre R. Burkhard, François Lazeyras, Jacqueline Delavelle, Denis F. Hochstrasser, Antoine Hadengue, François Terrier, Emiliano Giostra, Gilles Mentha, Laurent Spahr, Renaud DuPasquier |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Cirrhosis medicine.medical_treatment Encephalopathy Liver transplantation Parkinsonian Disorders/physiopathology Gastroenterology ddc:616.0757 Central nervous system disease Postoperative Complications Parkinsonian Disorders Internal medicine medicine Humans ddc:576 Hepatic encephalopathy Postoperative Complications/physiopathology Aged Retrospective Studies ddc:616 Transplantation Manganese Manganese/blood business.industry Parkinsonism Middle Aged medicine.disease Magnetic Resonance Imaging Hyperintensity Surgery ddc:616.8 Liver Transplantation Liver Transplantation/physiology Hepatic Encephalopathy Hepatic Encephalopathy/surgery Female business |
| Zdroj: | Transplant International, Vol. 15, No 4 (2002) pp. 188-95 |
| ISSN: | 0934-0874 |
| Popis: | Pallidal hyperintensity at magnetic resonance imaging (MRI) correlates to blood manganese (Mn) levels and parkinsonian signs in patients with cirrhosis. Similarly, metabolite changes in the basal ganglia (BG) at proton spectroscopy are related to these neurological signs. The evolution of these abnormalities after liver transplantation (OLT) is incompletely described. We evaluated 14 unselected consecutive patients with cirrhosis (minimal hepatic encephalopathy [HE] n=8, no HE n=6) before and 4 months after successful OLT for the evolution of parkinsonism using a validated scale (the United Parkinson's Disease Rating Scale, or UPDRS). Pallidal intensity at MRI, spectroscopic changes in the BG at magnetic resonance spectroscopy (MRS), and whole blood manganese concentrations were measured. After OLT in patients with preoperative minimal HE, the UPDRS scores improved, but mild parkinsonism persisted (16.1+/-3.6 to 6.2+/-4.8, P |
| Databáze: | OpenAIRE |
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