Chloride-Assisted Peptide Macrocyclization
| Autor: | Nikola Cindro, Tamara Rinkovec, Davide Riva, Gordan Horvat, Giovanna Speranza, Nikolina Vidović, Vladislav Tomišić |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Salts Anions Peptides Proteins Cyclization Titration 010405 organic chemistry Organic Chemistry Peptide 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Chloride Cyclic peptide 0104 chemical sciences chemistry medicine Physical and Theoretical Chemistry medicine.drug |
| Popis: | The role of the Cl- anion as a templating agent for the synthesis of cyclopeptides was assessed through the preparation of three new homocyclolysines and other six cyclic peptides by head-to-tail lactamization. Isolated yields of products obtained by chloride-templating approach were considerably higher than those gained by a cation-promoted procedure, whereby, in some cases, only the anion-assisted synthesis yielded the desired cyclopeptides. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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